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1

Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits

Tobias Wunberg, Martin Hendrix, Alexander Hillisch, Mario Lobell, Heinrich Meier, Carsten Schmeck, Hanno Wild, Berthold Hinzen

Journal:

Drug Discovery Today

Year:

2006

Language:

english

File:

PDF, 254 KB

english, 2006

2

Antibakterielle Naturstoffe in der medizinischen Chemie – Exodus oder Renaissance?

Franz von Nussbaum, Michael Brands, Berthold Hinzen, Stefan Weigand, Dieter Häbich

Journal:

Angewandte Chemie

Year:

2006

Language:

german

File:

PDF, 2.41 MB

german, 2006

3

Titelbild: Antibakterielle Naturstoffe in der medizinischen Chemie – Exodus oder Renaissance? (Angew. Chem. 31/2006)

Franz von Nussbaum, Michael Brands, Berthold Hinzen, Stefan Weigand, Dieter Häbich

Journal:

Angewandte Chemie

Year:

2006

Language:

german

File:

PDF, 153 KB

german, 2006

4

Antibacterial Natural Products in Medicinal Chemistry—Exodus or Revival?

Franz von Nussbaum, Michael Brands, Berthold Hinzen, Stefan Weigand, Dieter Häbich

Journal:

Angewandte Chemie International Edition

Year:

2006

Language:

english

File:

PDF, 2.42 MB

english, 2006

5

Cover Picture: Antibacterial Natural Products in Medicinal Chemistry—Exodus or Revival? (Angew. Chem. Int. Ed. 31/2006)

Franz von Nussbaum, Michael Brands, Berthold Hinzen, Stefan Weigand, Dieter Häbich

Journal:

Angewandte Chemie International Edition

Year:

2006

Language:

english

File:

PDF, 153 KB

english, 2006

6

ChemInform Abstract: Rapid Assembly of Oligosaccharides: 1,2-Diacetal-mediated Reactivity Tuning in the Coupling of Glycosyl Fluorides.

Daniel K. Baeschlin, Luke G. Green, Michael G. Hahn, Berthold Hinzen, Stuart J. Ince, Ley Steven V. Ley Steven V.

Journal:

Year:

2000

File:

PDF, 31 KB

2000

7

Encoding Strategies for Combinatorial Libraries

Berthold Hinzen

Journal:

Year:

2003

File:

PDF, 49 KB

2003

8

Polymer-Supported Reagents: Preparation and Use in Parallel Organic Synthesis

Berthold Hinzen

Journal:

Year:

2003

File:

PDF, 49 KB

2003

9

Erythropoietin Sensitizer — A Case Study

Berthold Hinzen, Gabriele Braunlich, Christoph Gerdes, Thomas Kramer, Klemens Lustig, Ulrich Nielsch, Michael Sperzel, Josef Pernerstorfer

Journal:

Year:

2004

File:

PDF, 68 KB

2004

10

Medicinal Chemistry Optimization of Acyldepsipeptides of the Enopeptin Class Antibiotics

Berthold Hinzen, Siegfried Raddatz, Holger Paulsen, Thomas Lampe, Andreas Schumacher, Dieter Häbich, Veronica Hellwig, Jordi Benet-Buchholz, Rainer Endermann, Harald Labischinski, Heike Brötz-Oesterhe

Journal:

Year:

2006

Language:

english

File:

PDF, 305 KB

english, 2006

11

In Silico ADMET Traffic Lights as a Tool for the Prioritization of HTS Hits

Mario Lobell, Martin Hendrix, Berthold Hinzen, Jörg Keldenich, Heinrich Meier, Carsten Schmeck, Rudolf Schohe-Loop, Tobias Wunberg, Alexander Hillisch

Journal:

Year:

2006

Language:

english

File:

PDF, 255 KB

english, 2006

12

Cover Picture: Medicinal Chemistry Optimization of Acyldepsipeptides of the Enopeptin Class Antibiotics (ChemMedChem 7/2006)

Berthold Hinzen, Siegfried Raddatz, Holger Paulsen, Thomas Lampe, Andreas Schumacher, Dieter Häbich, Veronica Hellwig, Jordi Benet-Buchholz, Rainer Endermann, Harald Labischinski, Heike Brötz-Oesterhe

Journal:

Year:

2006

File:

PDF, 36 KB

2006

13

Mimicking the Vancomycin Carboxylate Binding Site: Synthetic receptors for sulfonates, carboxylates, and N-protected α-amino acids in water

Berthold Hinzen, Paul Seiler, François Diederich

Journal:

Helvetica Chimica Acta

Year:

1996

Language:

english

File:

PDF, 1.33 MB

english, 1996

14

Rapid assembly of oligosaccharides: 1,2-diacetal-mediated reactivity tuning in the coupling of glycosyl fluorides

Daniel K Baeschlin, Luke G Green, Michael G Hahn, Berthold Hinzen, Stuart J Ince, Steven V Ley

Journal:

Tetrahedron: Asymmetry

Year:

2000

Language:

english

File:

PDF, 414 KB

english, 2000

15

Dysregulation of bacterial proteolytic machinery by a new class of antibiotics

Brötz-Oesterhelt, Heike, Beyer, Dieter, Kroll, Hein-Peter, Endermann, Rainer, Ladel, Christoph, Schroeder, Werner, Hinzen, Berthold, Raddatz, Siegfried, Paulsen, Holger, Henninger, Kerstin

Journal:

Nature Medicine

Year:

2005

Language:

english

File:

PDF, 432 KB

english, 2005

16

Polymer supported perruthenate (PSP): a new oxidant for clean organic synthesis

Hinzen, Berthold, Ley, Steven V.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1997

Language:

english

File:

PDF, 34 KB

english, 1997

17

[Methods and Principles in Medicinal Chemistry] Combinatorial Chemistry (From Theory to Application) || CC Bond-Forming Reactions

Bannwarth, Willi, Hinzen, Berthold

Year:

2006

Language:

english

File:

PDF, 3.69 MB

english, 2006

18

Use of polymer supported reagents for clean multi-step organic synthesis: preparation of amines and amine derivatives from alcohols for use in compound library generation

Ley, Steven V., Bolli, Martin H., Hinzen, Berthold, Gervois, Anne-Geraldine, Hall, Beverley J.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1998

Language:

english

File:

PDF, 131 KB

english, 1998

19

[Methods and Principles in Medicinal Chemistry] Combinatorial Chemistry (From Theory to Application) || Purification Principles in High-Speed Solution-Phase Synthesis

Bannwarth, Willi, Hinzen, Berthold

Year:

2006

Language:

english

File:

PDF, 383 KB

english, 2006

20

[Methods and Principles in Medicinal Chemistry] Combinatorial Chemistry (From Theory to Application) || Linkers for Solid-Phase Organic Synthesis (SPOS) and Combinatorial Approaches on Solid Supports

Bannwarth, Willi, Hinzen, Berthold

Year:

2006

Language:

english

File:

PDF, 1.80 MB

english, 2006

21

[Methods and Principles in Medicinal Chemistry] Combinatorial Chemistry (From Theory to Application) || Cyclative Cleavage: A Versatile Concept in Solid-Phase Organic Chemistry

Bannwarth, Willi, Hinzen, Berthold

Year:

2006

Language:

english

File:

PDF, 829 KB

english, 2006

22

[Methods and Principles in Medicinal Chemistry] Combinatorial Chemistry (From Theory to Application) || Encoding Strategies for Combinatorial Libraries

Bannwarth, Willi, Hinzen, Berthold

Year:

2006

Language:

english

File:

PDF, 49 KB

english, 2006

23

[Methods and Principles in Medicinal Chemistry] Combinatorial Chemistry (From Theory to Application) || Automation and Devices for Combinatorial Chemistry and Parallel Organic Synthesis

Bannwarth, Willi, Hinzen, Berthold

Year:

2006

Language:

english

File:

PDF, 486 KB

english, 2006

24

[Methods and Principles in Medicinal Chemistry] Combinatorial Chemistry (From Theory to Application) || Polymer-Supported Reagents: Preparation and Use in Parallel Organic Synthesis

Bannwarth, Willi, Hinzen, Berthold

Year:

2006

Language:

english

File:

PDF, 450 KB

english, 2006

25

[Methods and Principles in Medicinal Chemistry] Combinatorial Chemistry (From Theory to Application) || Front Matter

Bannwarth, Willi, Hinzen, Berthold

Year:

2006

Language:

english

File:

PDF, 131 KB

english, 2006

26

Clean three-step synthesis of 4,5-dihydro-1H-pyrazoles starting from alcohols using polymer supported reagents

Haunert, Frank, Bolli, Martin H., Hinzen, Berthold, Ley, Steven V.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1998

Language:

english

File:

PDF, 86 KB

english, 1998

27

Synthesis of isoxazolidines using polymer supported perruthenate (PSP)

Hinzen, Berthold, Ley, Steven V.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1998

Language:

english

File:

PDF, 76 KB

english, 1998

28

One-pot Synthesis of Penta- and Hepta-saccharides from Monomeric Mannose Building Blocks Using the Principles of Orthogonality and Reactivity Tuning

Green, Luke, Hinzen, Berthold, Ince, Stuart J., Langer, Peter, Ley, Steven V., Warriner, Stuart L.

Journal:

Year:

1998

Language:

english

File:

PDF, 59 KB

english, 1998

29

Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease

Famulla, Kirsten, Sass, Peter, Malik, Imran, Akopian, Tatos, Kandror, Olga, Alber, Marina, Hinzen, Berthold, Ruebsamen-Schaeff, Helga, Kalscheuer, Rainer, Goldberg, Alfred L., Brötz-Oesterhelt, Heike

Journal:

Molecular Microbiology

Year:

2016

Language:

english

File:

PDF, 2.14 MB

english, 2016

30

[Methods and Principles in Medicinal Chemistry] Combinatorial Chemistry (From Theory to Application) || Combinatorial Synthesis of Heterocycles

Bannwarth, Willi, Hinzen, Berthold

Year:

2006

Language:

english

File:

PDF, 1.70 MB

english, 2006

31

[Methods and Principles in Medicinal Chemistry] Combinatorial Chemistry (From Theory to Application) || Appendix: Cheminformatics and Web Resources for Combinatorial Chemistry

Bannwarth, Willi, Hinzen, Berthold

Year:

2006

Language:

english

File:

PDF, 40 KB

english, 2006

32

[Methods and Principles in Medicinal Chemistry] Combinatorial Chemistry (From Theory to Application) || Assays for High-Throughput Screening in Drug Discovery

Bannwarth, Willi, Hinzen, Berthold

Year:

2006

Language:

english

File:

PDF, 603 KB

english, 2006

33

[Methods and Principles in Medicinal Chemistry] Combinatorial Chemistry (From Theory to Application) || Computer-Assisted Library Design

Bannwarth, Willi, Hinzen, Berthold

Year:

2006

Language:

english

File:

PDF, 959 KB

english, 2006

34

[Methods and Principles in Medicinal Chemistry] Combinatorial Chemistry (From Theory to Application) || Index

Bannwarth, Willi, Hinzen, Berthold

Year:

2006

Language:

english

File:

PDF, 45 KB

english, 2006